There are 63 Football Bowl Subdivision matchups on the Week 13 schedule, with Duke (-6.5) among the best bets versus the spread, according to our projections. For more tips, including parlay opportunities, scroll down.

Get computer predictions and insights for that matchup and more in this article.

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College Football Computer Picks - Best Spread Bets

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Pick: Duke -6.5 vs. Pittsburgh

  • Matchup: Pittsburgh Panthers at Duke Blue Devils
  • Projected Favorite & Spread: Duke by 19.3 points
  • Time: 12:00 PM ET
  • Date: November 25
  • TV Channel: ACC Network
  • Live Stream: Fubo

Pick: Memphis -13 vs. Temple

  • Matchup: Memphis Tigers at Temple Owls
  • Projected Favorite & Spread: Memphis by 23.6 points
  • Time: 12:00 PM ET
  • Date: November 24
  • TV Channel: ESPN
  • Live Stream: Fubo

Pick: Florida State -6.5 vs. Florida

  • Matchup: Florida State Seminoles at Florida Gators
  • Projected Favorite & Spread: Florida State by 16.8 points
  • Time: 7:00 PM ET
  • Date: November 25
  • TV Channel: ESPN
  • Live Stream: Fubo

Pick: UMass +2.5 vs. UConn

  • Matchup: UConn Huskies at UMass Minutemen
  • Projected Favorite & Spread: UMass by 7.5 points
  • Time: 12:00 PM ET
  • Date: November 25
  • TV Channel: ESPN+
  • Live Stream: ESPN+

Pick: Arizona -10.5 vs. Arizona State

  • Matchup: Arizona Wildcats at Arizona State Sun Devils
  • Projected Favorite & Spread: Arizona by 20.0 points
  • Time: 3:30 PM ET
  • Date: November 25
  • TV Channel: ESPN
  • Live Stream: Fubo

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College Football Computer Picks - Best Total Bets

Over 41.5 - Wyoming vs. Nevada

  • Matchup: Wyoming Cowboys at Nevada Wolf Pack
  • Projected Total: 50.7 points
  • Time: 9:00 PM ET
  • Date: November 25
  • TV Channel: CBS Sports Network
  • Live Stream: Fubo

Over 37 - Eastern Michigan vs. Buffalo

  • Matchup: Eastern Michigan Eagles at Buffalo Bulls
  • Projected Total: 45.5 points
  • Time: 7:30 PM ET
  • Date: November 21
  • TV Channel: ESPN2
  • Live Stream: Fubo

Over 26 - Iowa vs. Nebraska

  • Matchup: Iowa Hawkeyes at Nebraska Cornhuskers
  • Projected Total: 34.1 points
  • Time: 12:00 PM ET
  • Date: November 24
  • TV Channel: CBS
  • Live Stream: Fubo

Under 68.5 - Washington State vs. Washington

  • Matchup: Washington State Cougars at Washington Huskies
  • Projected Total: 60.6 points
  • Time: 4:00 PM ET
  • Date: November 25
  • TV Channel: FOX
  • Live Stream: Fubo

Over 49.5 - Florida State vs. Florida

  • Matchup: Florida State Seminoles at Florida Gators
  • Projected Total: 56.7 points
  • Time: 7:00 PM ET
  • Date: November 25
  • TV Channel: ESPN
  • Live Stream: Fubo

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