Senior receiver Matt VandeBerg injured his foot in practice on Monday and will be out indefinitely.
Akrum Wadley scored the go-ahead touchdown in the fourth quarter as Iowa opens Big Ten play with a 14-7 road victory.
The Cyclones forced four turnovers and turned those into 23 points in their 44-10 win.
Dubuque improve to 4-0 on the season and 2-0 in conference play with the win over the Norse.
The Peacocks scored 21 points in the third quarter to pick up their first win of the season.